%0 Journal Article
%T Liposome-Encapsulated Tamoxifen Citrate: A Breakthrough Approach to Enhance Therapeutic Effectiveness
%A Sachin Namdeo Kothawade
%A Vishal Vijay Pande
%A Sandesh Sachhidanand Bole
%A Prashant Bapusaheb Patil
%A Rajashri Balasaheb Sumbe
%A Vaibhav Sudhakar Wagh
%A Jayprakash Sitaram Suyrawanshi
%A Kalyani Appasaheb Autade
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2023
%V 13
%N 3
%R 10.51847/vqv7dbJpxc
%P 38-43
%X The objective of this study was to create a brand-new liposomal Tamoxifen Citrate formulation with an enhanced therapeutic index. The thin film hydration process was used to create the liposomes, and several formulations with different lipid compositions (lecithin and cholesterol), drug-to-lipid ratios, and amounts of amine-bearing lipids (stearyl amine) were examined. The hydration temperature and time were also studied to optimize the liposome attributes. Utilizing optical microscopy, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and surface morphology analysis, the size and encapsulation effectiveness of the liposomes were assessed. The parameters of in vitro drug release were examined in 0.9% w/v saline medium, and the impact of stearyl amine concentration on the release rate of Tamoxifen Citrate was looked into.

The results showed that Tamoxifen Citrate was encapsulated into the liposomes with an entrapment efficiency of 77.54% and 81% with lipid and amine-bearing lipid, respectively. The stability of the liposomes was assessed for 3 weeks under defined storage conditions, and the release kinetics of the Tamoxifen Citrate liposomes was studied. In vitro release studies indicated that the maximum drug release was up to 18 hours, demonstrating the potential of this liposomal formulation as a novel, prolonged delivery system with reasonable drug loading and desirable liposome properties. In conclusion, a liposomal Tamoxifen Citrate formulation with desired attributes was successfully prepared and showed promising results as a novel drug delivery system. 
%U https://eijppr.com/article/liposome-encapsulated-tamoxifen-citrate-a-breakthrough-approach-to-enhance-therapeutic-effectivenes-y2fsl414jdlkkdz