Intricate Network Between Inflammation; Immunity; Cancer- From Tumor Prevention to Tumor Initiation, Tumor Promotion and Tumor Progression

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Inflammation is a reaction to noxious stimulants. During acute inflammation release of inflammatory mediator’s are cytokines, growth factors, and proteolytic enzymes by immune cells such as neutrophils are predominant cells, NK cells, DC’s, and macrophages results in cellular repair and regeneration. If the same inflammation is aggravated chronically by immune cells such as macrophages are predominant cells followed by T cells, B cells, by releasing immune mediators such as cytokines, growth factors, and enzymes results in offensive action against epithelial cells, immune cells, vascular tissue, and resulting in pro-tumoral activities. Inflammation has adual role in cancer either it can prevent or promote cancer mainly driven by transcription factors such as NF-KB, STAT3 key transcription factors activated in development of immune cells to tumor progression in all the stages of cancer. This article highlights about the inflammatory mediators in acute and chronic inflammatory- microenvironment involved in various cellular- immunologic and vascular changes.