Human fungal diseases demonstrate a dangerous medical problem. For thousands of years, plant metabolites have performed a highly significant part in health preservation and protection from diseases. The current study detects the potentiality of solvent extracts of A. marina and S. monoicaas an antifungal agent. Solvent extracts of A. marina and S. monoica were prepared in (ethanol, methanol and acetone). Antidermatophytic activity of them was evaluated against T. mentagrophytes, T. verrucosum M. gallinae, M. gypseum, M. canis, E. floccosum, C. albicans and C. tropicalis using dry weight method. The results show that M. gypseum was the most sensitive for ethanol and methanol extracts of S. monoica while M. gallinae was the most sensitive for acetone extract of A. marina. The acetone extracts of A. marina and S. monoica were moreover undergo to the determination of the minimal inhibitory concentrations using different concentrations which the MIC value of different extracts was found to be different but in the range of (0.075- 0.5 mg/ml). The anti-oxidant activity and total phenolic content for all solvent extracts and defined, acetone extract of S. monoicahave the highest anti-oxidant activity (77 %) whereas methanol extract of A. marina havethe highest amount of phenolic content (47.04 mg/gdw). In addition, some bioactive compounds from solvent extracts separated and estimated by using high performance liquid chromatography.