Diabetes mellitus (DM) is one of the oldest known human diseases and one of the biggest health problems of researchers. Many studies have shown diabetes complications in different body organs. In the present study, diabetes mellitus (DM) was induced via administration of 40 mg/kg Streptozotocin (STZ), intraperitoneally. Rats were divided into three groups, control group (n=5), diabetes group (n=10), and diabetes treated with Punica granatum peel (n=10) (3 ml/animal). The study continued for 4 weeks. The liver was processed for examination under a light microscope. The results showed many pathologic changes in the liver tissue in diabetic rat, which were seen by different changes appearing in the liver tissue such as several necrotic cells, atrophic nucleus, and acute tissue deformities. While the tissues treated with Punica granatum showed a significant improvement in liver tissue of the diabetic rats treated with Punica granatum compared to the diabetic control rats group.