%0 Journal Article
%T Excipient Compatibility as a Predictive Problem for Botanical Actives Across Chemical Stability, Interfacial Interactions, Processing Conditions, and Dosage-Form Performance
%A Elena Fedorova
%A Alexey Volkov
%A Irina Morozova
%A Dmitry Kuznetsov
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2026
%V 16
%N 4
%R 10.51847/k5UWV2QnSY
%P 10-19
%X Excipient compatibility is commonly treated as a screening property assigned to a drug–excipient pair, yet formulation failure usually emerges from a material system exposed to a particular environment and manufacturing history. This problem is amplified for botanical actives, whose solid state, intermolecular organization, carrier association, and chemical lability can change with formulation architecture. This original pharmaceutical-science framework reframes compatibility as a context-conditioned prediction problem spanning chemical degradation, moisture and oxygen exposure, microenvironmental pH, interfacial interactions, processing stress, and dosage-form performance. The analysis distinguishes intrinsic material attributes from state variables created by composition, storage, and processing; separates evidence of interaction from evidence of mechanism; and treats formulation performance as a downstream consequence rather than a surrogate definition of compatibility. A proposed predictive architecture integrates active identity and state, excipient grade and functionality, environmental exposure, process history, interface characteristics, analytical evidence, and endpoint-specific outcomes. Predictions are positioned as hypotheses for experimental prioritization rather than final compatibility verdicts, with orthogonal confirmation and model updating required before transfer across formulations. The framework is particularly cautious for complex botanical mixtures, where composition, batch variability, unidentified constituents, and co-solute effects may exceed available molecular representations. The approach therefore does not provide a universal compatibility score or validated decision threshold. Instead, it organizes how formulation-relevant context can be preserved so that compatibility failure can be forecast, interrogated, and revised more systematically before long-term stability and dosage-form performance are fully known.
%U https://eijppr.com/article/excipient-compatibility-as-a-predictive-problem-for-botanical-actives-across-chemical-stability-int-6oiauvlidbvspp1