The present study was to evaluate the antifertility potential of Melia azedarach leaf extract (methanol) on female Wistar rats. The antifertility activity of the methanolic extract of the leaf was evaluated by two methods namely an anti-implantation activity study and an oestrous cycle study in female rats. Female rats were given methanolic extract for anti-implantation activity from the first to the seventh day of pregnancy. On the tenth day, laprotomization was done to determine how many numbers of implants, the number of resorption sites, and the number of corpora lutea. The extract was given for 15 days in the estrous cycle trial to cover three typical estrous cycles. Every morning, a vaginal smear off each animal was examined, and the length of the each phase of the cycle was recorded. At doses of 100 mg and 200 mg/kg, respectively, the methanolic extract demonstrated substantial antiimplantation action of 56.25% and 67.86%. In comparison to the control group, the methanolic extract significantly increased the duration of the dioestrous stage and significantly decreased the duration of the meta oestrous phase. Due to the presence of phytoestrogens such as Preg-4-en-3-one, 17. alpha. -hydroxy-17. beta. -cyano, the methanolic extract of Melia azedarach leaf shows antifertility activity.