TY  - JOUR
T1  - Effect of Artesunate on Serum Bilirubin and Albumin in Swiss Wistar Rats
A1  - Amaechi Eze Odono
A1  - Uchejeso Mark Obeta
A1  - Nkereuwem Sunday Etukudoh
A1  - David Ogobuchi Ali
JF  - International Journal of Pharmaceutical And Phytopharmacological Research
JO  - Int J Pharm Phytopharmacol Res
SN  - 2250-1029
Y1  - 2021
VL  - 11
IS  - 6
DO  - 10.51847/8XI7ujhDVb
SP  - 8
EP  - 14
N2  - Patients often take antimalarial drugs indiscriminately without a doctor’s prescription as treatment for uncomplicated malaria in the tropics, especially in Africa, where malaria is endemic. If these patients eventually visit clinicians during complications, the clinicians request liver functions tests, which include Serum bilirubin and albumin, from the medical laboratories before making clinical decisions. The study was done to evaluate the effects of artesunate (antimalarial) on serum bilirubin and albumin of Wistar rats. The study was conducted on a total of 30 rats (5 groups of 6 rats each). Rats in the control group were given distilled water only while those in test groups were administered with 2.0mg/kg, 4.0mg/kg, 8.0mg/kg, and 16.0mg/kg of artesunate, respectively. Bilirubin was estimated using Jendrassik and Grof method while Albumin was estimated using Bromocresol green binding method (BCG). The results and statistical analysis indicated remarkable differences (P 0.05) between the test and control groups. The marked increase in total bilirubin was dose-dependent and attributed to unconjugated hyperbilirubinaemia resulting from increased lysis of red blood cells initiated by the drug. People in malaria-endemic areas and who take antimalarials often should evaluate their liver functions at least once a year. 
UR  - https://eijppr.com/article/effect-of-artesunate-on-serum-bilirubin-and-albumin-in-swiss-wistar-rats-nlyft4hb0hhxcd6
ER  -