%0 Journal Article
%T Development of Paracetamol Tablets by Using Novel Coprocessed Granulation Binder-Disintegrant
%A Sharwaree Rajan Hardikar
%A Trupti Rajendrakumar Patil
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2022
%V 12
%N 4
%R 10.51847/33LE0rgRDk
%P 1-7
%X Established disintegrating agents possess the disintegrating ability only and they rarely assist in the compactibility of powder blend except for starch. Many of the reported binders are proven to retard the release rate of the active drug from the dosage forms. Therefore the present work was aimed at developing a co-processed binder-disintegrant to overcome these functional drawbacks of the binders and disintegrating agents. The novel binder-disintegrant was prepared by co-processing crospovidone and the gel obtained from the husk of Plantago Ovata seeds. To confirm the functionality of the novel co-processed binder-disintegrant under investigation; paracetamol was selected as a model drug. The absence of chemical interaction between the co-processed materials and the formation of hydrogen bonding between them was confirmed by the analytical technique of ATR-FTIR. The functionality of the co-processed material as a granulation binder was confirmed by the Heckel treatment. The linear relationship between ln (1/1-D) and compression pressure applied on the paracetamol tablets, confirmed the functionality of co-processed material as a granulation binder. These tablets were prepared by adding the novel co-processed granulation binder-disintegrant intra-granularly at 5%. The functionality of novel co-processed material as a disintegrating agent was confirmed by analyzing the results of disintegration and dissolution studies of the paracetamol tablets. Paracetamol tablets exhibited faster disintegration when crospovidone was added extra granularly; than when a novel co-processed binder disintegrant was added. Thus, the functionality of the novel binder disintegrant was investigated by assessing the performance of the formulation of immediate-release tablets of paracetamol. 
%U https://eijppr.com/article/development-of-paracetamol-tablets-by-using-novel-coprocessed-granulation-binder-disintegrant-2m5hdd46inoihlu