The article is devoted to the analysis of barriers to the introduction of innovations in the health care of the Russian Federation and the development of proposals for their mitigation. The author justifies the relevance and significance of the topic of study. The following groups of barriers to innovation in the healthcare of the Russian Federation are considered: barriers to the use and produce innovative medicines, barriers to innovative medical equipment and reagents, barriers to apply information and communication technologies, barriers to the protection of intellectual property. It is concluded that these obstacles hinder the introduction into the Russian market and the use of innovative medicines, medical equipment, as well as the full use of information and communication capabilities. All these reduce the availability of high-quality medical care to the general population of the country. The proposals made by the author aimed at mitigating and eliminating the identified barriers and minimizing the consequences of their impact. It is emphasized that in the future, concept statements specification and bringing them to the level of structured integrated practical solutions with financial and economic justifications are required.