Background : Diabetes is an ever-growing problem since the advent of imperial fast-food chains. Many people in developed and developing countries are facing obesity and diabetes co-pandemic. An important complication of diabetes is diabetic foot ulceration, an injury resulting from neural and vascular damage after years of poor glycemic control. Objectives : The purpose of this study is to review the literature and discuss the risk factors and prevention of diabetic foot ulceration. Methodology : PubMed database was used for articles selection, from where the papers were obtained and reviewed. PubMed database was used for articles selection and the following key terms: Diabetic foot ulcer, Risk factors, and Prevention. Conclusion : The best treatment is prevention of risk factors and recurrence of diabetic foot ulceration. This is best achieved by a multidisciplinary approach. Education of the population results in adherent and compliant patients and in-turn promptly reduces infections and ulcerations.