The present work is aimed to explore the earlier optimization approaches made using design of experiments (DoE). An intensive search made by referring peer-reviewed journals on DoE made on nanosuspensions. Handsome successful attempts that were made in the optimization of Nano suspensions by DoE were brought in one platform and presented in this paper. The study concludes that and gives a desktop reference to the new researchers in finding out the earlier attempts which were made on nanosuspensions using DoE in a short span.