%0 Journal Article
%T A Comparative Study on Interactions and Influence of Alkalizers on Dissolution Rate of Telmisartan
%A Talasila Eswara Gopala Krishna Murthy
%A Neelapala Dhanalakshmi
%A Alahari Ramya
%A Kapu Ranjith
%J International Journal of Pharmaceutical And Phytopharmacological Research
%@ 2250-1029
%D 2023
%V 13
%N 4
%R 10.51847/nGDU7Yz6Pp
%P 33-39
%X For preformulation studies in formulation development, compatibility studies are crucial. Telmisartan is an angiotensin II receptor blocker [ABRs]. It is also used in the treatment of heart attack and stroke. It is a BCS class II drug. Since telmisartan's solubility is pH-dependent, a few alkalizing agents are utilized to speed up the solubility and dissolution process. The objective of this study was to enhance the solubility of telmisartan. Alkalizing agents such as magnesium hydroxide, sodium bicarbonate, aluminium hydroxide, and barium carbonate are used. Telmisartan solid dispersions with the selected alkalinising agents were formulated by employing a kneading technique and subjected to IR spectral, HPLC and in-vitro dissolution studies. Magnesium hydroxide was found to be preferable compared to other alkalizers based on docking, IR spectral and HPLC techniques and in-vitro dissolution studies. The results demonstrated the enhanced solubility of telmisartan with magnesium hydroxide and sodium lauryl sulphate at ratios. This study concluded that addition of alkalising agent like magnesium hydroxide improves solubility of class – II drugs. 
%U https://eijppr.com/article/a-comparative-study-on-interactions-and-influence-of-alkalizers-on-dissolution-rate-of-telmisartan-am6jriuzembbhqz